Cancer cell stiffening via CoQ₁₀ and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer.

ABSTRACT: CoQ₁₀ (Coenzyme Q₁₀) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ₁₀ is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development and progression. Here, we show that CoQ₁₀ and its biosynthetic enzyme UBIAD1 play a critical role in plasmamembrane mechanical properties that are of interest for breast cancer (BC) progression and treatment. CoQ₁₀ and UBIAD1 increase membrane fluidity leading to increased cell stiffness in BC. Furthermore, CoQ₁₀ and UBIAD1 states impair ECM (extracellular matrix)-mediated oncogenic signaling and reduce ferroptosis resistance in BC settings. Analyses on human patients and mou

SUBMITTER: Tosi G 

PROVIDER: S-EPMC11410950 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature