Decoupling of strain- and intrastrain-level interactions of microbiomes in a sponge holobiont.

ABSTRACT: Holobionts are highly organized assemblages of eukaryotic hosts, cellular microbial symbionts, and viruses, whose interactions and evolution involve complex biological processes. It is largely unknown which specific determinants drive similarity or individuality in genetic diversity between holobionts. Here, we combine short- and long-read sequencing and DNA-proximity-linkage technologies to investigate intraspecific diversity of the microbiomes, including host-resolved viruses, in individuals of a model marine sponge. We find strong impacts of the sponge host and the cellular hosts of viruses on strain-level organization of the holobiont, whereas substantial overlap in nucleotide diversity between holobionts suggests frequent exchanges of microbial cells and viruses at intrastrain level i

SUBMITTER: Wang W 

PROVIDER: S-EPMC11410982 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature