White matter tract integrity in isolated oral clefts: relationship to cognition and reading skills.

ABSTRACT: Children with isolated cleft of the lip and/or palate (iCL/P) have been shown to be at risk for impaired reading ability. Structural and functional neuroimaging studies have revealed subtle morphological and functional abnormalities correlated to cognition and reading ability. However, the integrity of white matter tracts and their potential relationship to reading performance in iCL/P is under-studied. The purpose of the present study was to evaluate white matter integrity related to cognition and reading skills among participants with and without iCL/P. Data from two cross-sectional, case/control studies with similar neuropsychological batteries and diffusion tensor imaging (DTI) protocols were combined. The final sample included 210 participants (ages 7 to 27 years). Group and sex diffe

SUBMITTER: Goodwin JW 

PROVIDER: S-EPMC11411015 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature