Data-driven, connectome-wide analysis identifies psychosis-specific brain correlates of fear and anxiety.

ABSTRACT: Decades of psychosis research highlight the prevalence and the clinical significance of negative emotions, such as fear and anxiety. Translational evidence demonstrates the pivotal role of the amygdala in fear and anxiety. However, most of these approaches have used hypothesis-driven analyses with predefined regions of interest. A data-driven analysis may provide a complimentary, unbiased approach to identifying brain correlates of fear and anxiety. The aim of the current study was to identify the brain basis of fear and anxiety in early psychosis and controls using a data-driven approach. We analyzed data from the Human Connectome Project for Early Psychosis, a multi-site study of 125 people with psychosis and 58 controls with resting-state fMRI and clinical characterization. Multivariate

SUBMITTER: Feola B 

PROVIDER: S-EPMC11411017 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature