Targeted proteomics of cerebrospinal fluid in treatment naive multiple sclerosis patients identifies immune biomarkers of clinical phenotypes.

ABSTRACT: Multiple sclerosis (MS) is an inflammatory demyelinating disease with heterogeneous clinical presentations and variable long-term disability accumulation. There are currently no standard criteria to accurately predict disease outcomes. In this study we investigated the cross-sectional relationship between disease phenotype and immune-modulating cytokines and chemokines in cerebrospinal fluid (CSF). We analyzed CSF from 20 DMT-naïve MS patients using Olink Proteomics' Target 96 Inflammation panel and correlated the resulting analytes with respect to (1) disease subtype, (2) patient age and sex, (3) extent of clinical disability, and (4) MRI segmental brain volumes. We found that intrathecal IL-4 correlated with higher Expanded Disability Status Scale (EDSS) scores and longer 25-foot walk ti

SUBMITTER: Rabin A 

PROVIDER: S-EPMC11411093 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature