Transcriptional profiling in microglia across physiological and pathological states identifies a transcriptional module associated with neurodegeneration.

ABSTRACT: Microglia are the resident immune cells of the central nervous system and are involved in brain development, homeostasis, and disease. New imaging and genomics technologies are revealing microglial complexity across developmental and functional states, brain regions, and diseases. We curated a set of publicly available gene expression datasets from human microglia spanning disease and health to identify sets of genes reflecting physiological and pathological microglial states. We also integrated multiple human microglial single-cell RNA-seq datasets in Alzheimer's disease (AD), multiple sclerosis (MS), and Parkinson's disease, and identified a distinct microglial transcriptional signature shared across diseases. Analysis of germ-line DNA identified genes with variants associated with AD an

SUBMITTER: Guvenek A 

PROVIDER: S-EPMC11411103 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature