Asymmetric dihydroboration of allenes enabled by ligand relay catalysis.

ABSTRACT: Catalytic asymmetric hydroboration of unsaturated bonds has been recognized as the most straightforward method for the construction of chiral organoboron compounds. Although catalytic asymmetric hydroboration of alkenes has been well-developed, enantioselective hydroboration of allenes still remains rare probably due to the challenges in controlling the enantio-, stereo-, and regioselectivity. Additionally, the hydroboration products might go through over-borohydride, making the catalytic asymmetric dihydroboration of allenes challenging. Here, we report a cobalt-catalyzed asymmetric dihydroboration of allenes using a ligand relay strategy with two simple ligands. This protocol shows excellent enantio-, stereo-, and regioselectivity with positive functional group compatibilities in the con

SUBMITTER: Lei Y 

PROVIDER: S-EPMC11411108 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature