Characterization of tumor suppressors and oncogenes evaluated from TCGA cancers.

ABSTRACT: Mutations in oncogenes and tumor suppressor genes can significantly impact cellular function during cancer development. A comprehensive analysis of their mutation patterns and significant gene ontology terms can provide insights into cancer emergence and suggest potential targets for drug development. This study analyzes twelve cancer subtypes by focusing on significant genetic and molecular factors. Two common genetic mutations associated with cancer are single nucleotide variants (SNVs) and copy number alterations (CNAs). Oncogenes, derived from mutated proto-oncogenes, disrupt normal cell functions and promote cancer, while tumor suppressor genes, often inactivated by mutations, regulate cell processes like proliferation and DNA damage response. This study analyzed datasets from The Can

SUBMITTER: Shen C 

PROVIDER: S-EPMC11411158 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature