Predictors of functioning in treatment-resistant schizophrenia: the role of negative symptoms and neurocognition.

ABSTRACT:

Introduction

Predictors of functioning are well-studied in schizophrenia, but much less so in treatment-resistant schizophrenia (TRS). In this study, we aim to investigate contributions of schizophrenia symptom domains and neurocognition to predict functioning in a TRS population (n = 146).

Methods

Participants were assessed on the Positive and Negative Syndrome Scale (PANSS), to calculate scores for five symptom factors (Positive, Negative, Cognitive, Depressive and Hostility) and two negative symptom constructs (Diminished Expressivity (DE), and Social Anhedonia (SA) as part of the Motivation and Pleasure-related dimension), based on a previously validated model, modified in accordance with EPA guidelines on negative symptoms assessment. Neurocognition was assessed with sy

SUBMITTER: Li Y 

PROVIDER: S-EPMC11411185 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature