Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern.

ABSTRACT: The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants, some of which are resistant to vaccines and drugs targeting viral elements. Targeting host dependency factors, e.g. cellular proteins required for viral replication, would help prevent the development of resistance. However, it remains unclear whether different SARS-CoV-2 variants induce conserved cellular responses and exploit the same core host factors. To this end, we compared three variants of concern and found that the host transcriptional response was conserved, differing only in kinetics and magnitude. Clustered regularly interspaced short palindromic repeats screening identified host genes required for each variant during infection. Most of the genes were shared by multiple variants. We validated our

SUBMITTER: Frasson I 

PROVIDER: S-EPMC11411213 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature