The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) Trial: A Trial Protocol.

ABSTRACT:

Importance

Intravenous fluids are an essential part of treatment in sepsis, but there remains clinical equipoise on which type of crystalloid fluids to use in sepsis. A previously reported sepsis subphenotype (ie, group D) has demonstrated a substantial mortality benefit from balanced crystalloids compared with normal saline.

Objective

To test the hypothesis that targeting balanced crystalloids to patients with group D sepsis through an electronic health record (EHR) alert will reduce 30-day inpatient mortality.

Design, setting, and participants

The Precision Resuscitation With Crystalloids in Sepsis (PRECISE) trial is a parallel-group, multihospital, single-blind, pragmatic randomized clinical trial to be conducted at 6 hospitals in the Emory Healthcare system. Patie

SUBMITTER: Bhavani SV 

PROVIDER: S-EPMC11411385 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature