Precision phenylalanine sensing in blood with nanomaterial-enhanced electrodes.

ABSTRACT: Phenylketonuria (PKU) is a genetic disorder associated with the metabolic dysfunction of the phenylalanine hydroxylase enzyme, which catalyses the conversion of l-phenylalanine (Phe) to l-tyrosine. Elevated levels of phenylalanine disrupt the central nervous system by impairing the myelination process and leading to mental retardation. Currently, commonly used diagnostic methods for PKU include the Guthrie test, liquid chromatography, and tandem mass spectrometry, all of which necessitate sophisticated infrastructure and costly equipment. Conversely, electrochemical detection methods hold promise in clinical diagnosis due to their high accuracy, rapid response time, and user-friendly nature. The choice of electrodes in electrochemical methods significantly influences sensitivity and analyt

SUBMITTER: Akyilmaz I 

PROVIDER: S-EPMC11411416 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature