Comorbidity and Disease Activity in Multiple Sclerosis.

ABSTRACT:

Importance

Multiple studies suggest that comorbidity worsens clinically relevant outcomes in multiple sclerosis (MS), including the severity of disability at diagnosis and rate of disability worsening after diagnosis. However, less is known regarding the association of comorbidity with measures of disease activity, such as relapse rate and magnetic resonance imaging lesion accrual, which are relevant to clinicians and clinical trialists.

Objective

To evaluate the association of comorbidities with disease activity in clinical trials of disease-modifying therapies (DMTs) in populations with MS.

Design, setting, and participants

A 2-stage meta-analytic approach was used in this cohort study of individual participant data from phase 3 clinical trials of MS DMTs that had 2

SUBMITTER: Salter A 

PROVIDER: S-EPMC11411448 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature