Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis.

ABSTRACT:

Importance

The epidemiological link between immune-mediated diseases (IMIDs) and cardiovascular disease has often been attributed to systemic inflammation. However, the direction of causality and the biological mechanisms linking cardiovascular disease with IMIDs are incompletely understood. Given the robust epidemiological association and the growing body of supportive mechanistic evidence, psoriasis is an exemplary IMID model for exploring this relationship.

Objective

To assess the bidirectional relationships between genetic predictors of psoriasis and the 2 major forms of cardiovascular disease, coronary artery disease (CAD) and stroke, and to evaluate the association between genetic predictors of cardiovascular disease with 9 other IMIDs.

Design, setting, and particip

SUBMITTER: Ramessur R 

PROVIDER: S-EPMC11411451 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature