Preparation and Characterization of Zein-Metformin/Gelatin Nanofibers by Coaxial Electrospinning.

ABSTRACT: Metformin is a drug commonly used for the treatment of type 2 diabetes. However, it has been associated with damaging side effects when used over a long period of time. A potential solution to this problem is the implementation of a prolonged-release system for metformin, which would enhance the efficiency of the doses administered to patients. To achieve this, it is necessary to use materials compatible with humans. Electrospinning is an efficient technique that can be employed for this purpose, utilizing solvents that are safe for human use. Therefore, the objective of this study was to prepare and characterize a system for the prolonged release of metformin from zein and gelatin through coaxial electrospinning as well as to investigate its in vitro release. Metformin-loaded zein/gelatin

SUBMITTER: Montano-Grijalva EA 

PROVIDER: S-EPMC11411526 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature