An analysis of the physicochemical properties of oral drugs from 2000 to 2022.

ABSTRACT: Calculable physicochemical descriptors are a useful guide to assist compound design in medicinal chemistry. It is well established that controlling size, lipophilicity, hydrogen bonding, flexibility and shape, guided by descriptors that approximate to these properties, can greatly increase the chances of successful drug discovery. Many therapeutic targets and new modalities are incompatible with the optimal ranges of these properties and thus there is much interest in approaches to find oral drug candidates outside of this space. These considerations have been a focus for a while and hence we analysed the physicochemical properties of oral drugs approved by the FDA from 2000 to 2022 to assess if such concepts had influenced the output of the drug-discovery community. Our findings show that

SUBMITTER: Pirie R 

PROVIDER: S-EPMC11411612 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature