A novel aurone RNA CAG binder inhibits the huntingtin RNA-protein interaction.

ABSTRACT: Huntington's disease (HD) is a devastating, incurable condition whose pathophysiological mechanism relies on mutant RNA CAG repeat expansions. Aberrant recruitment of RNA-binding proteins by mutant CAG hairpins contributes to the progress of neurodegeneration. In this work, we identified a novel binder based on an aurone scaffold that reduces the level of binding of HTT mRNA to the MID1 protein in vitro. The obtained results introduce aurones as a novel platform for the design of functional ligands for disease-related RNA sequences.

SUBMITTER: Ballarin G 

PROVIDER: S-EPMC11411626 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature