Anoikis-related genes in breast cancer patients: reliable biomarker of prognosis.

ABSTRACT:

Background

Breast cancer (BC) is the most common cancer in women, and its progression is closely related to the phenomenon of anoikis. Anoikis, the specific programmed death resulting from a lack of contact between cells and the extracellular matrix, has recently been recognized as playing a critical role in tumor initiation, maintenance, and treatment. The ability of cancer cells to resist anoikis leads to cancer progression and metastatic colonization. However, the impact of anoikis on the prognosis of BC patients remains unclear.

Method

This study utilized data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to collect transcriptome and clinical data of BC patients. Anoikis-related genes (ARGs) were classified into subtypes A and B through

SUBMITTER: Tang M 

PROVIDER: S-EPMC11411761 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature