Effect of factor VIII and FVIII/PC ratio on portal vein thrombosis in liver cirrhosis: a systematic review and meta‑analysis.

ABSTRACT:

Background

To date, there is an ongoing debate regarding the ability to predict PVT development using markers of FVIII or FVIII/PC ratio. This study presents evidence-based medical findings on the influence of FVIII activity levels and FVIII/PC values in the formation of PVT in cirrhosis.

Methods

The search for original studies on risk factors for portal vein thrombosis (PVT) associated with cirrhosis was conducted, which primarily focused on comparing circulating FVIII activity levels or FVIII/PC ratio in cirrhotic patients with and without PVT. The quality of evidence from each study was assessed using the Newcastle-Ottawa Scale.

Results

The meta-analysis included a total of 10 original studies. In total, 2250 cirrhotic patients were included, with 414 having PVT an

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11411769 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature