Low-dose pro-resolving mediators temporally reset the resolution response to microbial inflammation.

ABSTRACT:

Background

Specialized pro-resolving mediators (SPMs) promote resolution of inflammation, clear infections and stimulate tissue regeneration. These include resolvins, protectins, and maresins. During self-resolving acute inflammation, SPMs are produced and have key functions activating endogenous resolution response for returning to homeostasis. Herein, we addressed whether infections initiated with ongoing inflammation alter resolution programs, and if low-dose repetitive SPM regimen re-programs the resolution response.

Methods

Inflammation was initiated with zymosan (1 mg/mouse) followed by E. coli (10⁵ CFU/mouse) infections carried out in murine peritonitis, and exudates collected at 4-72 h. Leukocytes were enumerated using light microscopy, percentages of PMN,

SUBMITTER: Serhan CN 

PROVIDER: S-EPMC11411770 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature