Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection.

ABSTRACT:

Background

Stunting and pubertal delay are common among children growing up with human immunodeficiency virus (HIV) and are associated with bone and muscle impairments. We investigated factors associated with bone density and muscle function in adolescents living with HIV (ALWH).

Methods

The VITALITY trial (PACTR202009897660297) investigated whether vitamin D and calcium supplementation improves musculoskeletal health among ALWH. A total of 842 ALWH aged 11-19 years, established on antiretroviral therapy (ART) for ≥6 months, were enrolled from HIV clinics in Zambia and Zimbabwe. Clinical history and examination were undertaken, and serum 25-hydroxyvitamin D₃ (25[OH]D₃) was measured. Dual-energy X-ray absorptiometry measured total-body-less-head bone min

SUBMITTER: Dzavakwa NV 

PROVIDER: S-EPMC11411771 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature