A single-center study of reference intervals for TAT, PIC, TM and t-PAIC in healthy older Chinese adults.

ABSTRACT:

Objective

To explore the distribution of thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin inhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) in healthy older Chinese adults, and establish the reference intervals (RIs).

Methods

The Biotech Shine i2900 chemiluminescence immune assay was used to measure the plasma concentrations of TAT, PIC, TM, and t-PAIC in 1628 adults ≥ 60 years. The RIs were established using the 2.5th and 97.5th percentiles of the distribution.

Results

TAT levels were lower in males than females across all ages. Differences between the ages of 60-79 and ≥ 80 in both sex groups were statistically significant, with an upward trend with age. PIC levels showed no difference between the se

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11411837 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature