Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems.

ABSTRACT: In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialized defense systems that are often clustered together on genomic islands. The O1 El Tor strains of Vibrio cholerae responsible for the ongoing seventh cholera pandemic (7PET) contain a characteristic set of genomic islands involved in host colonization and disease, many of which contain defense systems. Notably, Vibrio pathogenicity island 2 contains several characterized defense systems as well as a putative type I restriction-modification (T1RM) system, which, interestingly, is interrupted by two genes of unknown function. Here, we demonstrate that the T1RM system is active, methylates the host genomes of a representative set of 7PET strai

SUBMITTER: Vizzarro G 

PROVIDER: S-EPMC11411939 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature