TolC and EmrA1 contribute to Francisella novicida multidrug resistance and modulation of host cell death.

ABSTRACT: Francisella spp. are Gram-negative, facultative intracellular pathogens. Francisella tularensis causes the human disease tularemia and is considered a biological threat agent due to its high infectivity and virulence. A central aspect of Francisella virulence is its ability to dampen host immune responses. We previously identified the outer membrane channel (OMC) protein TolC as a critical F. tularensis virulence factor required for suppression of apoptotic and proinflammatory responses during macrophage infection. TolC functions as part of multidrug efflux systems and the type I secretion pathway that exports bacterial effector proteins. In these systems, TolC forms tripartite complexes together with an inner membrane transporter and periplasmic membrane fusion

SUBMITTER: Kopping EJ 

PROVIDER: S-EPMC11411944 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature