Response of <i>Staphylococcus aureus</i> physiology and Agr quorum sensing to low-shear modeled microgravity.

ABSTRACT: Staphylococcus aureus is commonly isolated from astronauts returning from spaceflight. Previous analysis of omics data from S. aureus low Earth orbit cultures indicated significantly increased expression of the Agr quorum sensing system and its downstream targets in spaceflight samples compared to ground controls. In this current study, the rotary cell culture system (RCCS) was used to investigate the effect of low-shear modeled microgravity (LSMMG) on S. aureus physiology and Agr activity. When cultured in the same growth medium and temperature as the previous spaceflight experiment, S. aureus LSMMG cultures exhibited decreased agr expression and altered growth compared to normal gravity control cultures, which are typically oriented with oxygenation mem

SUBMITTER: Hauserman MR 

PROVIDER: S-EPMC11411946 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature