Characterization of the angiomodulatory effects of Interleukin 11 cis- and trans-signaling in the retina.

ABSTRACT:

Background

The IL-6 cytokine family, with its crucial and pleiotropic intracellular signaling pathway STAT3, is a promising target for treating vasoproliferative retinal diseases. Previous research has shown that IL-6 cis-signaling (via membrane-bound receptors) and trans-signaling (via soluble receptors) can have distinct effects on target cells, leading to their application in various disease treatments. While IL-6 has been extensively studied, less is known about the angiogenic effects of IL-11, another member of the IL-6 family, in the retina. Therefore, the aim of this study was to characterize the effects of IL-11 on retinal angiogenesis.

Main text

In vitreous samples from proliferative diabetic retinopathy (PDR) patients, elevated levels of IL-11Rα, but not IL-11, wer

SUBMITTER: Liang P 

PROVIDER: S-EPMC11412048 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature