Simulation-based assessment of zwitterionic pendant group variations on the hemocompatibility of polyethersulfone membranes.

ABSTRACT: In the realm of hemodialysis, Polyethersulfone (PES) membranes dominate due to their exceptional stability and mechanical properties, capturing 93% of the market. Despite their widespread usage, the hydrophobic nature of PES introduces complications in hemodialysis, potentially leading to severe adverse reactions in patients with end-stage renal disease (ESRD) through protein fouling. Addressing this issue, our study focused on enhancing hemocompatibility by modifying PES surfaces with zwitterionic materials, known for their hydrophilicity and biological membrane compatibility. We investigated the functionalization of PES membranes utilizing various zwitterions in different ratios. Utilizing molecular docking, we examined the interactions of three zwitterionic ligands-carboxybetaine methac

SUBMITTER: Nazari S 

PROVIDER: S-EPMC11412084 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature