Inhaled Corticosteroids Use Before Hospitalization May Be Protective in Children With Direct Lung Injury.

ABSTRACT:

Background

Systemic corticosteroid use in acute respiratory failure has yielded uncertain benefits, partially because of off-target side effects. Inhaled corticosteroids (ICSs) confer localized antiinflammatory benefits and may protect adults with direct lung injury (DLI) from developing respiratory failure. To our knowledge, this relationship has not been studied in children.

Research question

Do children with DLI who are prescribed ICSs before hospitalization have lower odds of progressing to respiratory failure?

Study design and methods

This retrospective, single-center cohort identified children seeking treatment at the ED with DLI and medication records before hospitalization. The primary outcome was intubation; secondary outcomes included noninvasive respiratory

SUBMITTER: Landzberg E 

PROVIDER: S-EPMC11412107 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature