Neuroepigenetic Changes in DNA Methylation Affecting Diabetes-Induced Cognitive Impairment.

ABSTRACT: Chronic diabetic conditions have been associated with certain cerebral complications, that include neurobehavioral dysfunctional patterns and morphological alterations of neurons, especially the hippocampus. Neuroanatomical studies done by the authors have shown decreased total dendritic length, intersections, dendritic length per branch order and nodes in the CA1 hippocampal region of the diabetic brain as compared to its normal control group, indicating reduced dendritic arborization of the hippocampal CA1 neurons. Epigenetic alterations in the brain are well known to affect age-associated disorders, however its association with the evolving diabetes-induced damage in the brain is still not fully understood. DNA hypermethylation within the neurons, tend to silent the gene expression of s

SUBMITTER: Fernandes V 

PROVIDER: S-EPMC11412167 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature