Association of autoimmune diseases with the occurrence of osteoarthritis: a gene expression and Mendelian randomization study.

ABSTRACT:

Background

Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk of mortality among affected patients. However, whether a causal relationship exists between the two remains unknown.

Methods

In the Mendelian randomization (MR) study, we accessed exposure Genome-wide association study (GWAS) data from both the MRC Integrative Epidemiology Unit (MRC-IEU) and the FinnGen consortium. GWAS data for OA were obtained from MRC-IEU. We employed univariable, multivariable, and reverse MR analyses to explore potential associations between autoimmune disorders and OA. Additionally, a two-step mediation MR analysis was performed to investigate indirect factors possibly influencing the rela

SUBMITTER: Dan J 

PROVIDER: S-EPMC11412204 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature