Maternal vitamin D levels during pregnancy and offspring schizophrenia.

ABSTRACT:

Background

Findings from previous studies on maternal 25(OH)D levels during pregnancy and offspring schizophrenia are limited and inconsistent.

Methods

We used nationwide population-based register data with a nested case-control design to examine the association between maternal 25(OH)D levels during pregnancy and offspring schizophrenia. The cases of schizophrenia (n = 1145) were born from 1987 to 1997, and received a diagnosis of schizophrenia by 2017, and were matched with equal number of controls. A quantitative immunoassay was used to measure maternal 25(OH)D in archived maternal serum in the national biobank of the Finnish Maternity Cohort, collected during the first and early second trimesters. Conditional logistic regression models examined the association between ma

SUBMITTER: Sourander A 

PROVIDER: S-EPMC11412259 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature