Prospective Cytokine Profiling in Aqueous Humor Reveals a Proinflammatory Microenvironment in Highly Dense Nuclear Cataracts.

ABSTRACT:

Purpose

To investigate if the cytokine profile in the aqueous humor (AH) of cataract patients varies according to cataract type and severity.

Methods

This prospective study included 397 eyes of 397 patients (median age, 76 years; range, 30-94 years) who underwent standard small-incision phacoemulsification surgery. Cataracts were graded using the LOCS III system: mild (≤3), moderate (3.5-5), and severe (≥5). Biometric measurements from the IOL master 700 (Zeiss, Oberkochen, Germany) were used to differentiate between thick (>4.5 mm) and thin lenses. Information about age, gender, and self-reported diseases was obtained from patient records. Eleven different proteins were measured in AH using a multiplex cytokine assay (AYOXXA Biosystems, Cologne, Germany), including IL- 6, I

SUBMITTER: Latz C 

PROVIDER: S-EPMC11412381 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature