Surgical modeling of Chiari-like malformation in rats: Insights from canine morphology.

ABSTRACT:

Background

Chiari-like malformation in dogs and Chiari malformation type 1 in humans are conditions characterized by a relatively small caudal cranial fossa, leading to cerebellar herniation. This study aimed to develop a rat model of Chiari-like malformation using surgical techniques based on morphological characteristics observed in dogs.

Methods

Endocranial magnetic resonance images of both normal dogs and dogs diagnosed with Chiari-like malformation were retrospectively analyzed. Measurements of the caudal cranial fossa volume, rostral and medial fossa volume, and volume index were taken. The differences in caudal cranial fossa volume and volume index between normal dogs and those diagnosed with Chiari-like malformation were then utilized to create a rat model of Chiari-

SUBMITTER: Jung JH 

PROVIDER: S-EPMC11412529 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature