Congenital transmission of Chagas disease: The role of newborn therapy on the disease's dynamics.

ABSTRACT: Chagas disease, also known as American trypanosomiasis, is caused by a protozoan blood-borne pathogen called Trypanosoma cruzi. The World Health Organization (WHO) has classified Chagas as one of 21 neglected tropical diseases present in the world and estimates that 6-7 million people are currently infected with Chagas. Congenital transmission of Chagas disease contributes to a significant amount of new infections, especially in endemic areas where 22.5% of new infections are due to congenital transmission. In this paper, we investigate congenital transmission's impact on Chagas disease dynamics through a mathematical model. Specifically, we examine how treating a proportion of infants born to infected individuals impacts the progression and spread of Chagas disease. The influence of newbo

SUBMITTER: Boukaabar M 

PROVIDER: S-EPMC11412536 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature