IRE1α regulates ROS and immune responses after UVB irradiation.

ABSTRACT:

Objective

UV irradiation of the skin induces photo damage and generates cytotoxic intracellular reactive oxygen species (ROS), activating the unfolded protein response (UPR) to adapt or reduce these UVB-mediated damages. This study was designed to understand the role of the UPR mediator IRE1α in the antioxidant response following UVB irradiation of mouse skin and keratinocytes.

Methods

We used mice with an epidermal deletion of IRE1α and primary mouse keratinocytes to examine effects of UV on different parameters of the antioxidant response in the presence and absence of functional IRE1α.

Results

In the absence of IRE1α, PERK activity and protein levels are significantly compromised following UVB irradiation. Additionally, the loss of IRE1α suppressed phosphorylation

SUBMITTER: Son J 

PROVIDER: S-EPMC11412578 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature