Increased levels of anti-Encephalitozoon intestinalis antibodies in patients with colorectal cancer.

ABSTRACT:

Background

The prevalence of microsporidiosis in the general population, or within specific groups of individuals/patients, is largely underestimated. The absence of specific seroprevalence tools limits knowledge of the epidemiology of these opportunistic pathogens, although known since the 1980s. Since microsporidia hijack the machinery of its host cell and certain species multiply within intestinal cells, a potential link between the parasite and colorectal cancer (CRC) has been suggested.

Methodology/principal findings

To explore a potential epidemiological link between microsporidia and CRC, we evaluated the seroprevalence of Encephalitozoon intestinalis among CRC patients and healthy subjects using ELISA assays based on two recombinant proteins, namely rEiPTP1 and rEiSW

SUBMITTER: Nourrisson C 

PROVIDER: S-EPMC11412658 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature