Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 KO mice.

ABSTRACT:

Introduction

Fragile X syndrome is an inherited X-linked disorder associated with intellectual disabilities that begin in childhood and last a lifetime. The symptoms overlap with autism spectrum disorder, and the syndrome predominantly affects males. Consequently, FXS research tends to favor analysis of social behaviors in males, leaving a gap in our understanding of other behavioral traits, especially in females.

Methods

We used a mouse model of FXS to analyze developmental, behavioral, neurochemical, and transcriptomic profiles in males and females.

Results

Our behavioral assays demonstrated locomotor hyperactivity, motor impulsivity, increased "approach" behavior in an approach-avoidance assay, and deficits in nest building behavior. Analysis of brain neurotransmit

SUBMITTER: McCarthy DM 

PROVIDER: S-EPMC11412825 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature