Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks.

ABSTRACT:

Introduction

Cytoarchitectonic studies have uncovered a correlation between higher levels of cortical hierarchy and reduced dendritic size. This hierarchical organization extends to the brain's timescales, revealing longer intrinsic timescales at higher hierarchical levels. However, estimating the contribution of single-neuron dendritic morphology to the hierarchy of timescales, which is typically characterized at a macroscopic level, remains challenging.

Method

Here we mapped the intrinsic timescales of six functional networks using functional magnetic resonance imaging (fMRI) data, and characterized the influence of neuronal dendritic size on intrinsic timescales of brain regions, utilizing a multicompartmental neuronal modeling approach based on digitally reconstructed ne

SUBMITTER: Wu K 

PROVIDER: S-EPMC11412829 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature