Decreased consumption of natural rewards in rhesus monkeys with prolonged methamphetamine abstinence.

ABSTRACT:

Rationale

Relapse to drug use is a major clinical challenge in the treatment of addictive disorders, including psychostimulant use and may be exacerbated by reduced sensitivity to natural, non-drug reward. Given the relatively limited set of outcomes, and short withdrawal time in rodent studies, we conducted a more detailed assessment of the response to natural rewards in methamphetamine (METH) naive versus exposed monkeys during long-term abstinence.

Methods

This study introduced an improved sucrose preference test (iSPT) to assess natural reward seeking and consumption in monkeys with long-term abstinence after methamphetamine (METH) use. The test was administered to sixteen naive monkeys and five METH exposed monkeys that had been abstinent for at least 3 months.

Resul

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11412841 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature