Immune system dysfunction and inflammation in aging Shank3b mutant mice, a model of autism spectrum disorder.

ABSTRACT:

Introduction

Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental Q8 conditions characterized by deficits in social interaction/communication and restrictive/repetitive behaviors. Recent studies highlight the role of immune system dysfunction and inflammation in ASD pathophysiology. Indeed, elevated levels of pro-inflammatory cytokines were described in the brain and peripheral blood of ASD individuals. Despite this, how this pro-inflammatory profile evolves with aging and whether it may be associated with behavioral deficits is unknown. In this work, we explored the impact of aging on motor behavior and inflammation using Shank3b mutant mice, a model for syndromic ASD.

Methods

Using RT-qPCR and flow cytometry, we examined the expression of key pro-i

SUBMITTER: Cerilli E 

PROVIDER: S-EPMC11412883 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature