Disrupted basolateral amygdala circuits supports negative valence bias in depressive states.

ABSTRACT: Negative bias is an essential characteristic of depressive episodes leading patients to attribute more negative valence to environmental cues. This negative bias affects all levels of information processing including emotional response, attention and memory, leading to the development and maintenance of depressive symptoms. In this context, pleasant stimuli become less attractive and unpleasant ones more aversive, yet the related neural circuits underlying this bias remain largely unknown. By studying a mice model for depression chronically receiving corticosterone (CORT), we showed a negative bias in valence attribution to olfactory stimuli that responds to antidepressant drug. This result paralleled the alterations in odor value assignment we observed in bipolar depressed patients. Given

SUBMITTER: Bigot M 

PROVIDER: S-EPMC11412998 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature