Unraveling the role of gut microbiota by fecal microbiota transplantation in rat model of kidney stone disease.

ABSTRACT: Emerging research on the microbiome highlights the significant role of gut health in the development of kidney stones, indicating that an imbalance in gut bacteria or dysbiosis can influence the formation of stones by altering oxalate metabolism and urinary metabolite profiles. In particular, the overabundance of specific bacteria such as Enterococcus and Oxalobacter spp., which are known to affect oxalate absorption, is observed in patients with urolithiasis. This study investigates the effects of gut dysbiosis on urolithiasis through fecal microbiota transplantation (FMT) from patients to rats and its impact on urinary mineral excretion and stone formation. Fecal samples from eight patients with calcium oxalate stones and ten healthy volunteers were collected to assess the gut microbiome

SUBMITTER: Hunthai S 

PROVIDER: S-EPMC11412999 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature