A population-based study of familial coaggregation and shared genetic etiology of psychiatric and gastrointestinal disorders.

ABSTRACT:

Background

It has been proposed that having a psychiatric disorder could increase the risk of developing a gastrointestinal disorder, and vice versa. The role of familial coaggregation and shared genetic loading between psychiatric and gastrointestinal disorders remains unclear.

Methods

This study used the Taiwan National Health Insurance Research Database; 4,504,612 individuals born 1970-1999 with parental information, 51,664 same-sex twins, and 3,322,959 persons with full-sibling(s) were enrolled. Genotyping was available for 106,796 unrelated participants from the Taiwan Biobank. A logistic regression model was used to examine the associations of individual history, affected relatives, and polygenic risk scores (PRS) for schizophrenia (SCZ), bipolar disorder (BPD), major

SUBMITTER: Pan YJ 

PROVIDER: S-EPMC11413006 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature