Neural stimulation and modulation with sub-cellular precision by optomechanical bio-dart.

ABSTRACT: Neural stimulation and modulation at high spatial resolution are crucial for mediating neuronal signaling and plasticity, aiding in a better understanding of neuronal dysfunction and neurodegenerative diseases. However, developing a biocompatible and precisely controllable technique for accurate and effective stimulation and modulation of neurons at the subcellular level is highly challenging. Here, we report an optomechanical method for neural stimulation and modulation with subcellular precision using optically controlled bio-darts. The bio-dart is obtained from the tip of sunflower pollen grain and can generate transient pressure on the cell membrane with submicrometer spatial resolution when propelled by optical scattering force controlled with an optical fiber probe, which results in

SUBMITTER: Zhu G 

PROVIDER: S-EPMC11413014 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature