The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder.

ABSTRACT:

Background

Previous studies have established a connection between adverse childhood experiences (ACE) and alcohol use disorder (AUD), both of which are associated with alterations in grey matter volume (GMV) and cortical thickness (CT). The current study aimed to assess the neurobiological impact of ACE specifically in the context of AUD, as well as the role of maltreatment type (i.e., abuse or neglect) and timing.

Methods

Structural MRI data were collected from 35 adults with AUD (mean age: 40; 31% female) and 28 healthy controls (mean age: 36; 61% female). ACE were assessed retrospectively using the Childhood Trauma Questionnaire, and the Maltreatment and Abuse Chronology interview. Global and regional GMV and CT were estimated using voxel- and surface-based morphometry.

SUBMITTER: Turkmen C 

PROVIDER: S-EPMC11413060 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature