Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.

ABSTRACT: Disorders of consciousness (DoC) represent a challenging and complex group of neurological conditions characterised by profound disturbances in consciousness. The current range of treatments for DoC is limited. This has sparked growing interest in developing new treatments, including the use of psychedelic drugs. Nevertheless, clinical investigations and the mechanisms behind them are methodologically and ethically constrained. To tackle these limitations, we combined biologically plausible whole-brain models with deep learning techniques to characterise the low-dimensional space of DoC patients. We investigated the effects of model pharmacological interventions by including the whole-brain dynamical consequences of the enhanced neuromodulatory level of different neurotransmitters, and pro

SUBMITTER: Mindlin I 

PROVIDER: S-EPMC11413186 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature