Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence.

ABSTRACT:

Background

The genetic association between urticaria and mental disorders and whether inflammatory cytokines mediate this process remains unclear.

Materials and methods

A Mendelian randomization (MR) approaches to elucidate the causal relationship between urticaria and mental disorders and to validate the mediation of inflammatory cytokines. Genome-wide association study (GWAS) databases used were obtained from Psychiatric Genomics Cooperation (PGC), GWAS Catalog, and FinnGen Consortium. Our study was conducted using inverse variance weighted (IVW) and Bayesian weighted MR (BWMR) methods for joint analysis.

Results

The MR results showed that urticaria increased the risk of attention deficit hyperactivity disorder (ADHD) (odds ratio [OR] = $ = $ 1.088, 95% confidence

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11413335 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature