No relationship between male pubertal timing and depression - new insights from epidemiology and Mendelian randomization.

ABSTRACT:

Background

In males, the relationship between pubertal timing and depression is understudied and less consistent than in females, likely for reasons of unmeasured confounding. To clarify this relationship, a combined epidemiological and genetic approach was chosen to exploit the methodological advantages of both approaches.

Methods

Data from 2026 males from a nationwide, representative study were used to investigate the non-/linear relationship between pubertal timing defined by the age at voice break and depression, considering a multitude of potential confounders and their interactions with pubertal timing. This analysis was complemented by Mendelian randomization (MR), which is robust to inferential problems inherent to epidemiological studies. We used 71 single nucleotid

SUBMITTER: Hirtz R 

PROVIDER: S-EPMC11413349 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature