Reduced dorsal fronto-striatal connectivity at rest in anorexia nervosa.

ABSTRACT:

Background

Anorexia nervosa (AN) is a serious psychiatric illness that remains difficult to treat. Elucidating the neural mechanisms of AN is necessary to identify novel treatment targets and improve outcomes. A growing body of literature points to a role for dorsal fronto-striatal circuitry in the pathophysiology of AN, with increasing evidence of abnormal task-based fMRI activation within this network among patients with AN. Whether these abnormalities are present at rest and reflect fundamental differences in brain organization is unclear.

Methods

The current study combined resting-state fMRI data from patients with AN (n = 89) and healthy controls (HC; n = 92) across four studies, removing site effects using ComBat harmonization. First, the a priori

SUBMITTER: Muratore AF 

PROVIDER: S-EPMC11413358 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature