20-year neurocognitive development following a schizophrenia spectrum disorder and associations with symptom severity and functional outcomes.

ABSTRACT:

Background

Cognitive deficits are a core feature of schizophrenia and are closely associated with poor functional outcomes. It remains unclear if cognitive deficits progress over time or remain stable. Determining patients at increased risk of progressive worsening might help targeted neurocognitive remediation approaches.

Methods

This 20-year follow-up study examined neurocognitive outcomes of 156 participants from the OPUS I trial. Neurocognition was assessed using the brief assessment of cognition in schizophrenia at the 10- and 20-year follow-up, allowing us to examine changes in neurocognition over ten years.

Results

We found that 30.5% of patients had a declining course of neurocognition, 49.2% had a stable course of neurocognition and 20.3% experienced improvem

SUBMITTER: Starzer M 

PROVIDER: S-EPMC11413361 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature